Aesculin, CAS# 531-75-9

Analysis method: HPLC 13cNMR、1HNMR、MS
Molecular formula: C15H16O9
Molecular weight: 340.28214
CAS No.: 531-75-9
Apperance: White powder
Grade: 98%-99% （ HPLC ）
Packaging: As required.
Annual capacity: 1000 kgs
Storage condition: Refrigerate and protect from light.
Plant source: 秦皮/Fraxini Cortex

Esculin, also known as esculoside, belongs to the class of organic compounds known as coumarin glycosides. These are aromatic compounds containing a carbohydrate moiety glycosidically bound to a coumarin moiety. As a result, a total of 19 metabolites (10 phase I metabolites and 9 phase II metabolites) were found and identified. Esculin is an extremely weak basic (essentially neutral) compound (based on its pKa). The main activities of Esculine focus on capillary protection, as it improves capillary permeability and fragility. The antioxidant property might as well explain some of the anti-inflammatory activity of the product, making it a suitable product for after sun treatments, for example. After oral administration of esculin (100 mg/kg) for rats, plasma, urine, feces and bile samples were collected to screen metabolites. Esculine also showed good antioxidant properties, protecting triglycerides against auto-oxidation at high temperatures . Topically applied Esculine increases the “capillary density” (the number of capillaries open to flow per surface unit) and improves the morphological aspect of the smallest blood vessels. It was also found that after oral administration of esculin, the esculin could be metabolized to esculetin in vivo via deglycosylation, and esculetin was found in all biological samples. It is reported to inhibit catabolic enzymes such as hyaluronidase and collagenase, thus preserving the integrity of the perivascular connective tissue.

——Source: HMDB

Aesculin is one of our superior products. Tauto Biotech successfully extracted 98%-99% （ HPLC ） Aesculin by utilizing our own patented extraction method(HSCCC). Related technology is applicable to production lines with a scale of ≥1000 kgs.

Advantages: continuous supply, strict QA, HSCCC technology, annual production capacity ≥1000 kgs.

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